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doi: 10.1038/s41422-020-0379-5 258 SiesH

A potential caveat in interpreting CSE or CBS effects is that SQR-dependent oxidation of H 2 S (as generated by CSE or CBS) not only yields GSSH but also feeds electrons into the mitochondrial CoQ 10 pool

in contrast, GSS knockout depletes GSH but still permits glutamate consumption for -glutamyl-peptide synthesis, and does not alter ferroptosis sensitivity under cystine starvation

NAD+ is also required for enzymes involved in the synthesis of DNA, which is essential for cell division and growth, and the repair of DNA damage, thus protecting the body from age-related diseases