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One such option includes GLP-1 receptor agonists, which is a class of medications originally developed for diabetes, now widely used for medically supervised weight loss

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315 Subsequently, rats were treated with liraglutide through subcutaneous injection to observe its therapeutic effect on OA

The involvement of GLP-1 in PD can be simplified to the activation of the MAPK/extracellular signal-regulated kinase 1/2 (ERK) pathway, which has an important role in synaptic plasticity, and the PI3K/Akt pathway signaled by GLP-1 receptor stimulation and the subsequent increase in cAMP and PKA and PI3K activation [73]