Collagen & Hydration Boost: Combines collagen peptides with hyaluronic acid to support skin elasticity, firmness, and moisture retention for a smoother, more youthful-looking appearance and supple glow
Another double-blind RCT evaluating the administration of HA 120mg/d for 12 weeks reported a significant reduction in wrinkles and an increase in stratum corneum water content and skin elasticity and thickness.20 Similar results had been observed in earlier RCTs (Table 4)2123 and prospective studies.24 A study of the benefits of an oral eggshell supplement, which contains HA and collagen, showed an improvement in skin elasticity, a reduction in skin pigmentation, and very high patient satisfaction with facial softness, skin hydration, and hair and nail appearance.25 A double-blind RCT (n=88) with similar characteristics reported a reduction in periocular wrinkles and improved hair thickness and growth.26 Oral Tranexamic Acid The plasmin inhibitor tranexamic acid (TA) is a potent anti-inflammatory and depigmenting agent
Observed changes are paralleled with the excessive glutamate release from neurons and glial cells, (Belov Kirdajova et al
Most protocols recommend weekly or biweekly sessions initially, followed by monthly maintenance
A 2023 phase II trial in 40 post-surgical patients found 0.5% GHK-Cu gel reduced scar volume by 35% at 3 months versus silicone (p=0.002) (Hosokawa et al., 2023)
