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FDA-approved weight loss medications like semaglutide (Wegovy) and tirzepatide (Zepbound) have undergone large-scale clinical trials demonstrating statistically significant weight loss

FDA GRAS determination (2007): The FDA reviewed AOD-9604's toxicology data and granted Generally Recognized As Safe status for oral use as a food ingredient

Oral supplements or injections both show strong effects during this period

However, results vary depending on adherence and baseline metabolic function