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Peripheral blood samples were analyzed for concentrations of metalloproteinase (MMP)-9, tissue inhibitors of MMP (TIMP)-1,2, and myeloperoxidase (MPO)

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A cohort study in Avon was recently published in 2020, in which 13,433 children grouped by none, single, and multiple exposures to anesthesia were recruited, and the results indicated that multiple exposures might cause adverse effects on motor ability and social, linguistic ability (Walkden et al., 2020)

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Since B vitamins are water-soluble and excreted through urine, accumulation is minimal even with higher frequencies