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Clinical trials at doses up to 40mg daily for 12 weeks have reported no serious adverse effects (Brendler & Williamson, 2019, Phytomedicine )

The Akkermansia species muciniphila has been shown to alter glucose and lipid metabolism as well as intestinal immunity 86 , to strengthen the integrity of the enterocyte monolayer to possibly improve intestinal barrier integrity 87 , and to improve glucose tolerance and reduce visceral adipose tissue inflammation in mice fed an HFD 88

Moreover, the use of analgesic medications, such as opioids, can exacerbate this dysbiosis, damage the intestinal epithelial barrier function and promote the translocation of gut microbiota, which increased susceptibility to PND (Mora et al., 2012

doi: 10.1124/mol.63.4.908