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Other indirect ways to stimulate the antiepileptic effects of KD may lay in the alterations of the metabolism of neurotransmitters such as glutamate and gamma-amino butyric acid (GABA), and the activation of energy-sensing signaling pathways such as the PPAR, mammalian target of rapamycin (mTOR), and adenosine monophosphate-(AMP)-activated kinase (AMPK) pathways (71, 72)

Avoid taking levothyroxine with grapefruit juice, certain antacids, or high-fiber supplements

The mechanism of action involves several key processes

This personalized approach helps identify the lowest effective dose that controls appetite without causing problematic hypertension

Camilleri M, Cowen T, Koch TR