Lilly's first Phase 3 readout (TRIUMPH4) reported strong results in people with obesity/overweight and knee osteoarthritis, including: ~28.7% average weight loss at 68 weeks at the 12 mg dose (topline reporting), plus improvements in pain and function measures The important phrase there is "topline"
Convenience matters, especially if many people taking GLP-1s experience side effects like nausea, which may make meal prep difficult
Several studies report a significant effect of RYGB surgery on gut microbial composition and metabolic activity with a reduction in fecal short-chain fatty acids (SCFAs) [2,3,4,5], i.e., acetic-, propionic-, and butyric- acid which are the main metabolic outputs of colonic fermentation
Metabolic adaptation: is it really an illusion
At GoodRx we estimate that in the last year Americans have overspent by at least $200 million by paying full retail price for their weight-loss GIP and GLP-1 agonists