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In Novo Nordisk's clinical late-phase trial for obesity without type 2 diabetes, which included more than 300 adults, the participants who took the pill once daily lost an average of 16.6% of their body weight, or 39 pounds , compared with 2.7%, or 6 pounds, for those on a placebo

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Drinking adequate water is essential during any weight loss program and may reduce reported itching sensations

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In another hand, while most reports appear to implicate IGF-I as a potential mediator of pathological changes in the diabetic kidney[364, 365], IGF-I is also protective against oxidative stress and apoptosis induced by high levels of glucose in cultured mesangial cells