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Hydroquinone (HQ), another well-studied whitening agent, has been used clinically in leading cosmetic hyperpigmentation treatment 23 , however, it was also found to cause serious problems by generating reactive oxygen species leading to oxidative damage of lipids and permanent loss of melanocytes

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Adaptive phenotype After several weeks: increased mitochondrial number and density per fiber, shift from type IIa/IIx toward type I oxidative fibers, increased muscle capillarization, improved maximum aerobic capacity (VO2max), increased endurance