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No peer-reviewed clinical trials have demonstrated safety or efficacy of concurrent semaglutide-tirzepatide use, which means prescribers lack evidence to support this combination

Reeves, Metabolic consequences of obesity and insulin resistance in polycystic ovary syndrome: diagnostic and methodological challenges

If the out-of-pocket cost seems overwhelming, ask about manufacturer assistance, mail-order options, or a therapeutically appropriate on-formulary alternative

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Michael Zezas: Okay, so a lot of good insights there