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Compare this to 11.8% with cagrilintide alone and 16.1% with semaglutide alone
To increase aqueous solubility of the compounds to facilitate structural studies, the cycloheptyl substituent in TGR uncompetitive inhibitor 8 was replaced with a sugar moiety, resulting in compound 9 , a noncompetitive inhibitor and thus capable of binding the enzyme in absence of NADPH
All the cultures were incubated at 30 C and 220 rpm for 24 h
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