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Phase 1 safety trials must determine maximum tolerated dose and identify adverse effects

Certain immunomodulatory effects, such as IL-2 stimulation, are mediated via nuclear receptors rather than membrane MT1/MT2 receptors

When these algae experience stress such as intense sunlight, nutrient scarcity, or high salinity they begin producing astaxanthin as a shield to protect their cells from oxidative damage.16 Many marine animals feed on these algae, such as:17 Salmon Shrimp Krill Trout Flamingos These animals absorb and store the pigment in their tissues, which gives them their distinctive pink or reddish coloration.18 What makes astaxanthin compelling is that the same compound algae use to shield their cells from light, heat, and environmental stress may also help human cells withstand similar challenges

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Quek YLK, Li J, Fujimoto J, Zhang J, Chow CWB, Behrens C, Mao X, Correa A, Song X, Zhang J, Roarty EB, Thornton RL, Coyle MD, Antonoff MB, Kalhor N, Moran C, Weissferdt A, William Jr WN, Swisher SG , Lee JJ, Heymach JV, Wistuba IV, Futreal A, Zhang J