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It is approved only for HIV-associated lipodystrophy

IIS activates PI3K and Akt kinase

Because it degrades in blood in a pathway involving amino-peptidases, it may not be suitable for people who take medications that inhibit or are metabolized by peptidases (e.g., captopril, a treatment for hypertension).4 Also, based on what we know about other therapeutic peptides, we would say DSIP is contraindicated for women who are pregnant or breastfeeding as well as people with a personal history of cancer

However, regarding the nasal spray, microparticles are not expected to penetrate the mucin barrier that protects the respiratory epithelial cells (3941), and so this now motivates a deeper physicochemical evaluation of niclosamide and especially how to increase its concentration in solution using simple buffers to access the epithelial cells