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Unlike apoptosis, which involves caspase activation and nuclear fragmentation, ferroptosis is initiated by iron accumulation and lipid peroxidation, resulting in membrane rupture without caspase involvement ( This review aims to comprehensively analyze recent advances in understanding ferroptosis mechanisms in CHD and evaluate emerging clinical intervention strategies

A number of studies have shown that glutathione levels in the blood decrease with age

Preclinical studies Age-related declining NAD + levels in aging have been observed in rodents and different human tissues, such as muscle, liver, and brain 58,240,241

Knockdown of GLS2 but not GLS1 can inhibit cysteine starvation-mediated ferroptosis of MEFs [86]