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Furthermore, no studies to date have reported pharmacokinetic parameters (e.g., absorption, bioavailability, tissue distribution), nor have they conducted long-term toxicity assessments or evaluated reproductive outcomes in vivo

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Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis

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