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[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Gonzalez-Hurtado E, Lee J, Choi J, Wolfgang MJ

No peer-reviewed randomized controlled trial in humans has been completed as of the article's review date, which is a genuine limitation

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In the only published head-to-head skin study, GHK-Cu supported improved collagen in 70% of subjects versus 40% for tretinoin, though tretinoin still leads for surface texture and tone