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It has also been reported that prostaglandin E2 (PGE2) secretion and cyclooxygenase-2 (COX-2) expression were significantly increased in colon cells exposed to toxin A either in vivo or in vitro (Kim et al., 2007)

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In addition, regarding the relationship of HDACs expression pattern and the circuits known to be susceptible to seizures, there is scarce data until now