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The high molecular weight proteins of the mitochondrial matrix, which cannot move through the mPTP, also contribute to the increased colloidal osmotic pressure

Neonatal blood concentrations of metformin have been found to equal or surpass half of maternal levels, raising concerns about the potential impact of elevated metformin levels on neonatal glucose metabolism and the development of hypoglycemia in newborns

In addition, acyl-coA synthetase long chain family member 4 (ACSL4) and glutathione s-transferase zeta 1(GSTZ1) is required for sorafenib-induced lipid peroxidation and ferroptosis (146, 147)

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