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Although NADPH-oxidase activity during acute PE is the main source of ROS, this increase in ROS is necessary to induce GPx, CAT and SOD enzymes gene expression as well as mitochondrial biogenesis via NF-B (Henrquez-Olgun et al., 2016)

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10.1093/hmg/ddu328 Hum Mol Genet

Besides, it possesses high affinity with K i app s of 3 nM and 13 nM for ErbB1 and ErbB2, respectively