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In particular, up-regulation of the transcripts for the rate-limiting enzyme of the TCA cycle, 2-oxoglutarate dehydrogenase (OGDH), and for the TCA-cycle-affiliated proteins, such as subunits of pyruvate dehydrogenase (PDH) and branched chain 2-oxo acids dehydrogenase (BCODH) is observed

Chem Res Toxicol 24(11):1803

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Glutathione can cycle between reduced (GSH) and oxidized (GSSG) states, enabling this metabolite to participate in redox biochemical reactions [29, 30]