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doi: 10.1016/j.eplepsyres.2005.08.005

Pinealon doses may be gradually increased toward the target range

Meanwhile, MSC therapy research in other diseases has highlighted relevant potential risks (Tarte et al., 2010

To further mitigate risk, many studies involve sentinel subjects typically only 1 participant on the active drug and 1 on placebo who receives the investigational drug before the remaining participants in the cohort are dosed

El-Beltagy et al