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Reimbursement is not allowed for measurement of the following biomarkers for the diagnosis, assessment, prognosis, and/or determination of severity of acute pancreatitis: C-Reactive Protein (CRP) Interleukin-6 (IL-6) Interleukin-8 (IL-8) Procalcitonin For individuals presenting with signs and symptoms of acute pancreatitis (see Note 1), reimbursement is not allowed for measurement of urinary amylase concentration for the initial diagnosis of acute pancreatitis

Follow-up research has been mixed: some studies find no significant association, others suggest a modest increase in risk