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High-dose intravenous protocols (up to 50 mg/kg daily, ~3,500 mg for a 70 kg person) have been used safely in patients with metabolic disorders [8] , indicating a wide therapeutic margin

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multiple agent therapy wherein each agent is independently a sub-therapeutic dose, with either sequential or concurrent administration of the agents, will produce the desired pharmacological response, such as an erection sufficient for sexual intercourse, without producing the frequency or severity of adverse side effects observed at a sufficiently high dose of either agent administered as monotherapy that produces a comparable pharmacological response