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At the intracellular signaling level, mitogen-activated protein kinases (MAPKs), including JNK and p38, have been identified as central transducers of inflammatory signaling [199]

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Growth hormone plays a critical role in tissue repair and protein synthesis, so even modest increases in GH levels can translate to meaningful improvements in recovery capacity (5)

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Notably, recent studies found that Mn overexposure can also increase cellular Fe uptake, reduce antioxidant levels, resulting in increased lipid peroxidation and ferroptosis in both cells and mouse models (Wang et al., 2024)