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Consistently, the GPx3 levels were reported to be down-regulated in aggressive inflammatory breast cancer (IBC) carcinoma tissues compared to non-IBC tissues, and this down-regulation was associated with hypermethylation of the GPx3 promoter [103]

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Cell cycle regulators such as p53, cyclin D1, and p21 are also altered in diabetes, pushing cells toward apoptotic fate [244,245,246,247]