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References: Pickart, L., & Thaler, M
Most clinical evidence is topical-formulation cosmetic research, not injectable
Protective Effects of -Lipoic Acid and Chlorogenic Acid on Cadmium-Induced Liver Injury in Three-Yellow Chickens
In recent years, scientists have shown that intestinal dysbiosis is associated with chronically elevated leptin levels and decreased leptin sensitivity
But only the R-isomer (R-ALA) is naturally produced in the body and actively participates in mitochondrial energy metabolism.12 Some studies suggest that R-ALA may be more bioavailable than standard racemic ALA though the clinical significance of this difference is still under investigation.17 In addition, anecdotal reports and small studies indicate that R-ALA may be easier on digestion, with fewer gastrointestinal side effects than standard racemic ALA, especially at higher doses.18 However, R-ALA is chemically unstable on its own
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