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Mean body weight versus time profiles after intranasal administration of PT- N01, PT-N04, PT-N05 at single dose of 4 mg/animal and subcutaneous administration of PT- S01 at a single dose of 0.25 mg/animal in rabbits

Downstream analysis revealed significantly decreased expression of antioxidant proteins Nrf2 and HO-1, accompanied by increased phosphorylation of NF-B, indicating enhanced neuroinflammation and impaired antioxidant defenses