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Enhancement of peptide coupling to hydroxyapatite and implant osseointegration through collagen mimetic peptide modified with a polyglutamate domain

Fourth, verifying the correlation between combined markersincluding the abundance of specific genera (e.g., decreased Bifidobacterium), iron metabolism indicators (e.g., elevated serum hepcidin), and pro-ferroptotic metabolites (e.g., increased TMAO)and OA clinical phenotypes through large-sample clinical studies, and exploring their diagnostic or prognostic value

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No published study has tested this split approach directly, but the pharmacological logic holds: maximize both local concentration and systemic delivery