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Why TB Meningitis Has Resisted Better Treatment for Two Decades Tuberculosis primarily infects the lungs, but a small fraction of cases take a far more dangerous turn: the bacteria breach the blood-brain barrier, invade the central nervous system, and trigger a granulomatous inflammatory response that causes collateral damage to blood vessels, disrupts the blood-brain barrier, and kills neurons, as described in the StatPearls TBM chapter

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Taking it with meals helps absorption and reduces stomach upset