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Because robust human safety data are limited, it is difficult to give a definitive side-effect profile with meaningful incidence rates

Pigmentation Reduction: Kojic acid and antioxidants work synergistically to fade age spots, melasma, and post-acne pigmentation

Figure 2: Higher insulin levels increase transmethylation, raising homocysteine (Hcy) levels and reducing cysteine

A study of erythrocyte membrane fluidity found increased membrane surface fluidity in response to PYC as well as a further outcome of protection against lipid peroxidation either from chelating metal ions or quenching free radicals, or both (Sivonov et al., 2004)