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Furthermore, GLP-1RAs have been shown to mitigate psoriasis severity by modulating the innate immune system, specifically through interactions with i NKT cells [208]

Unfortunately, much remains uncertain about this connection

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Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation

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