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Recently, the first open label clinical study of exenatide, a long-acting GLP-1 agonist, in the treatment of PD showed long-lasting improvements in motor and cognitive function

It tells your brain that you're full, slows how quickly food leaves your stomach, and improves insulin sensitivity

10.1002/art.38260 73

This transport is mediated by anchoring and motor proteins that interact with the cytoskeleton, facilitating organelle movement across the neuron 12,13

In clinical trial results released in December 2025, people on the highest dose of retatrutide lost nearly 30 percent of their body weight in 68 weeks