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Once absorbed, NAC is deacetylated to cysteine in the body, which is then incorporated into glutathione via the enzyme gamma-glutamylcysteine synthetase

However, patients in high-risk groups (over 60, concurrent metformin use, vegan diet, post-bariatric surgery) may benefit from additional supplementation

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He D, Mao Q, Jia J, Wang Z, Liu Y, Liu T, et al

Second Nature was identified as the most effective provider in the National Diabetes Prevention Programme, based on NHS-published data in the BMJ