It consists of cellular responses that help protect us from pathogens (germs) such as bacteria, viruses, or fungi
These challenges span mechanistic understanding, therapeutic design, and clinical validation
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Though DAM has been detected across multiple neurological disease models, the composition of disease related microglia and macrophage clusters differs between diseasephagocytic subtype predominant in AD, while inflammatory subtype predominant in ALS (Wishart et al., 2023)