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Serious Risks and Who Should Not Take Zepbound More serious but less common risks from Zepbound include: Pancreatitis Gallbladder problems Kidney injury (usually linked to dehydration from vomiting or diarrhea) Severe allergic reactions Zepbound carries a boxed warning for thyroid C-cell tumours based on rodent studies, and is contraindicated in anyone with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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Gastrointestinal side effects like nausea and vomiting can lead to dehydration, which may make you more susceptible to heat-related illness during sun exposure