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To date, the presence of GLP-1R in the renal vasculature has been confirmed but not in the tubules ( Oxidative Stress/Inflammation GLP-1RAs have been shown to prevent renal oxidative stress by inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase through the activation of PKA and the production of cyclic adenosine monophosphate (cAMP)

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These results furthermore correlated with the reduction of CRP levels, which may suggest that anti-inflammatory action may be an important mechanism of the antidepressant effect of incretin-based drugs [121]

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