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As expected, positive control analyses showed lower risks of major adverse cardiovascular events and major adverse kidney events among GLP-1 RA initiators relative to DPP-4i initiators, whereas negative control outcomes (glaucoma and bone fracture) did not differ between groups ( Supplementary Table 2 )

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Purine metabolism takes place a significant part in maintaining cellular energy balance and nucleic acid synthesis, while being closely linked to inflammation regulation and oxidative stress