Groups, each comprising 30 male and 30 female Fischer 344 rats, were exposed to concentrations of ethylene oxide (purity 99.9%) of 18, 58, or 173 mg/m 3 , for 6 h/day, 5 days per week, over 12 weeks
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As a sensitivity analysis, a stricter improvement definition of MELD-3 2 (at least two-point decrease, representing a clinically meaningful change) was applied
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