Potential long-term risks such as pancreatitis, gallbladder disease, and lean muscle mass loss are still being evaluated in ongoing Phase 3 trials
Current Obesity Reports, 8 (2), 156164
If the cleft is bilateral (affecting both sides) and extensive, two surgeries may be necessary one for each side, performed several weeks apart to close the clefts
Human thyroid C-cells have very few GLP-1 receptors, and large clinical trials have not shown an increased risk compared to placebo
Its a tri-agnoist which activates the GLP-1 receptor, the GIP receptor, and the glucagon receptor and looks quite remarkable in clinical trials, showing upwards of 24% body weight loss in patients. The delivery methods of these drugs are also evolving