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Furthermore, bioavailability, preclinical pharmacokinetics, and toxicity studies are necessary before clinical trials can be pursued for development into immunomodulatory agents

(PubMed) Bauman WA, Shaw S, Jayatilleke E, Spungen AM, Herbert V

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On the regulatory side, the European Food Safety Authority (EFSA) has authorised a claim that glucomannan contributes to weight loss in the context of an energy-restricted diet at 3 g per day taken in three 1 g doses with water, subject to a mandatory choking warning for anyone with swallowing difficulty or inadequate fluid intake, and an authorised oat beta-glucan claim for maintenance of normal blood cholesterol at 3 g per day [6]

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