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In vivo studies confirmed that Ghrelin significantly activated the BMP6/SMAD1 signaling pathway in the brain tissue of AD mice, thereby inhibiting microglial ferroptosis, promoting microglial polarization toward the M2 phenotype, and ameliorating learning and memory deficits in AD mice ( In vitro , Neuritin activated the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway in A 1-42 -stimulated HT22 neuronal cells, leading to increased NADK activity and NADPH expression, reduced MDA and ROS levels, and inhibition of neuronal ferroptosis

Cancers, 14 (15), 3614

Neurosci Lett (2016) 612:1938

95% CI, 0.6-5.35) or 1 year (HR = 1.94

The injection can be taken at any time of day, as long as it is administered on the same day each week