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Reducing dose of insulin secretagogue or insulin may be necessary

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GH-excess in acromegalic patients and GH-transgenic animals can result in glomerular hyperfiltration, renal hypertrophy, and glomerulosclerosis

Mechanistically, the peptide perturbs the FOXO4 interaction with p53, which selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis (Figure 2, this novel senolytic did remove cells from the PDL9 chondrocytes, which was accompanied by significantly reduced levels of SA--gal staining