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The results directly indicated that the targeting motif RGD-binding peptide RGD-GHK almost totally suppressed the collagenase (MMP-1) expression, resisted H 2 O 2 -induced COL-1 degradation, and simultaneously promoted collagen synthesis compared with GHK alone for cell anti-aging performance

There was also a decrease in the biomarkers for oxidative stress and an improvement in immune markers

Summary IGF-1 LR3 solves a specific problem in IGF research: the short half-life of native IGF-1 due to IGFBP sequestration

Shakya et al