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scaling up production from the laboratory to a clinical setting requires maintaining stringent control over sensitive processes, where minor fluctuations can result in batch-to-batch variability and prohibitive costs [212]

Consistent with the screening results, cells lacking both SLC25A39 and SLC25A40 were unable to proliferate under standard culture conditions (Fig 3d, Extended Data Fig

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A B12 deficiency can be difficult to diagnose and is commonly confused with a folate deficiency