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3.6 GLP-1 RAs in clinical practice The cardioprotective properties of GLP-1 RAs seem to be mediated through CV risk factors modification
Standard of Care) study for alogliptin (58, 62), the Savor-TIMI-53 study (Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes MellitusThrombolysis in Myocardial Infarction 53) for saxagliptin (60, 63), the TECOS study (Trial Evaluating Cardiovascular Outcomes With Sitagliptin) for sitagliptin (59, 64) and the CARMELINA study (Cardiovascular safety and Clinical Outcome with Linagliptin) for linagliptin (61, 65)
The low representation of tirzepatide likely reflects its recent introduction in 2023 [11], whereas the high frequency of exenatide reports can be attributed to its earlier approval in 2005 [29]
[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Heneka M.T., Golenbock D., Latz E., Morgan D., Brown R
