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When exposed to negatively charged carboxylated polystyrene particles (40 nm and 200 nm), human epithelial cells internalize them via phagocytosis and macropinocytosis [24]

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Safety Concerns Reported Side Effects: Facial flushing Nausea Spontaneous erections (males) Darkening of existing moles and freckles Appetite suppression Fatigue Injection site reactions Serious Concerns: The relationship between Melanotan II and melanoma is complex and not definitively established