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In patients taking opioids for an extended period of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper [see DOSAGE AND ADMINISTRATION, and WARNINGS]

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DSIP has been found in the hypothalamus, limbic system, pituitary, and various peripheral tissues

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The enzymatic machinery responsible for gliotoxin biosynthesis, and metabolism, is encoded by a multi-gene cluster in A