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The Triterpenoid 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic Acid and its Derivatives Inhibit Mitochondrial Lon Protease Activity: A Potential Novel Pathway for the Induction of Lymphoma Cell Death

In Alcohol and Cancer (pp

In particular, the animal study 7 in which pharmacological inhibition of GPx activity significantly reduced brain infarct damage suggested that under reduced oxygen supply, H 2 O 2 may exert either physiological or protective roles in the brain through its metabolic degradation to oxygen by catalase compensating for the lack of oxygen that occurs in the tissue after an ischemic event

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The timeline and magnitude of these changes depend on the specific medication, duration of treatment, and individual patient factors