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Dysbiosis promotes a shift in TRP metabolism away from 5-HT and toward KYN, QA, and 3-HK, while simultaneously impairing intestinal barrier integrity and driving low-grade systemic inflammation, exaggerated cortisol reactivity, HPA-axis dysregulation, visceral adiposity, and cardiometabolic risk all features commonly comorbid with depression [178,179,180,181,182]

Peeling and blanching can eliminate up to 85% of residues by removing contaminated outer layers (Munir et al., 2024)

Zaboli et al., 2021)

Taken together, our findings suggest an attenuation, but not a blocking, of ketamines acute antidepressant effects with naltrexone pretreatment in a sample of patients with MDD

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